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What Is 7-Keto?

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Originally published on mensphysique.com on Sunday, 17 February 2013

http://www.rxmuscle.com/blogs/the-lab-supplement-school/7523-what-is-7-keto.html
keto7
For those of you who do not know what 7-Keto is, it is a metabolite of the hormone dehydroepiandrosterone (DHEA), which has gained popularity among those who are interested in battling the aging process. Keto-7 boosts immune function and helps to reduce body fat without the risk of conversion to estrogen and testosterone which characterizes DHEA.

Keto-7 (or 7-Keto) is a brand name for the chemical 3-acetyl-7-oxo-dehydroepiandros-terone which is a metabolite mainly produced in the adrenal glands and skin as well as the brain. Levels of this compound rise in the body until about age 20, then start to drop after age 30, declining by 50% by age 50. When Keto-7 levels drop, body fat and total body weight tend to increase, and immune function drops as well. In addition, since the decline in Keto-7 is more pronounced than that of cortisol, cortisol becomes dominant and further challenges the strength of the immune system. So it certainly makes sense to supplement the body with Keto-7 as we age.

Probably the best features of Keto-7 are that it carries no negative side effects, is rapidly absorbed and does not accumulate in the body over time. It counteracts the effect of circulating glucocorticoids such as cortisol, thereby conferring a protective effect on the body’s immune function. For those of you who are asking how it can enhance your health and performance, consider the fact that Keto-7 is a powerful thermogenic and can cause an appreciable increase in the body’s metabolic rate. The process by which Keto-7 does this is by enhancing the activity of three thermogenic enzymes which stimulate fatty acid oxidation. These enzymes drive liver cells to burn fatty acids for energy, resulting in lowered triglycerides. In addition, Keto-7 causes a surge in thyroid hormone activity which further stimulates fat oxidation. Another encouraging effect of Keto-7 on the body is that it improves the blood cholesterol profile. Though Keto-7 only has a slight effect on decreasing LDL cholesterol, it causes a significant increase in HDL levels, thus shifting the total cholesterol profile. Keto-7 also causes a significant rise in apolipo-protein A-1 which has a protective effect on cardiovascular health.

Many proponents of Keto-7 supplementation suggest combination therapy with both Keto-7 and DHEA. Both of these substances can work in tandem to boost estrogen and testosterone levels to optimum range. DHEA can cause facial hair growth and oily skin in women who take large amounts of DHEA, so the use of Keto-7 with a smaller dose of DHEA can eliminate this problem. DHEA cannot be administered to individuals with prostate cancer or breast cancer, which makes Keto-7 an acceptable alternative.

Make sure to supplement with Keto-7 in the morning when the body’s natural production is at its peak. I take my dose with my first meal in the morning, but you can also take this supplement on an empty stomach. Some proponents advise taking two doses daily, but I believe a 100 mg dose once daily in the morning suffices for most individuals. Avoid taking it in the evening, as it may stimulate brain activity and result in insomnia.

Keto-7 should be taken by anyone who wants to combat the aging process and improve body composition without adversely affecting natural hormonal levels of estrogen and testosterone.

Ironman Magazine January 2014 Hardbody Feature

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Hardbody Main Image

Click to access IRONMAN-JAN2014-HARDBODY.PDF

Please read the full article by clicking on the link above. In this article I mention SWAT Fuel 9mm thermogenic fat burner. What I love about this particular fat burner is that I have never, ever gotten the jitters or shakes from it, yet it is extremely effective in giving me great energy and the ability to focus on whatever task I am engaged in, whether it is seeing patients at work, lifting weights at the gym, or writing articles. This product keeps me going on days when I may be at risk of going through an energy slump. I enthusiastically recommend 9mm and 9mm+P (which contains an appetite suppressant) to those of you who want to accelerate fat loss, maintain focus and energy, and avoid the jitters.

Fenugreek Enhances Performance

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Originally published on mensphysique.com on Wednesday, 16 January 2013

http://www.rxmuscle.com/blogs/the-lab-supplement-school/7362-fenugreek-enhances-performance.html
fenugreek leaves and seeds (1)
Fenugreek (Trigonella foenum-graecum) is a plant indigenous to India and Northern Africa that has demonstrated effectiveness in treating sexual dysfunction and which can increase sexual arousal partially by boosting testosterone levels. Fenugreek also has a myriad of other benefits, among them reductions in cholesterol and lower fasting blood glucose levels in diabetics. For this article, let’s focus on performance related benefits which fenugreek offers.

A 2011 study which examined the effects of 600 milligrams of fenugreek extract versus placebo in men who suffered from erectile dysfunction found a significant increase in sexual arousal and stamina in the men who were supplemented with fenugreek. Fenugreek also helped to maintain a normal testosterone level in the test subjects. For many men, that is reason enough to supplement with this plant, but fenugreek also has a beneficial effect on body composition and strength.

One published study from 2010 examined 49 men who engaged in regular resistance training and had them supplement with either 500 milligrams of fenugreek extract daily or with a placebo. During this time, the participants continued a four-day per week weight training program. After eight weeks the subjects were assessed in their strength while performing bench presses and leg presses and also had their body fat measured. The men who were given fenugreek supplementation had significant improvements in both weight training strength and body fat percentage when compared with the group who were given the placebo. In addition, a measureable increase in testosterone levels was discovered in the men who took fenugreek.

The reason for the boost in testosterone which fenugreek confers is due to a substance known as diosgenin. Diosgenin is one of a class of substances known as steroidal saponins, substances which can be converted to the sex hormones testosterone, progesterone, and estrogen. In men, diosgenin increases the testosterone metabolite DHT, which is then converted easily to testosterone. For this reason, it may be especially helpful to take supplements with fenugreek in men who have fluctuating or low natural testosterone levels.

Why You Should Add Curcumin To Your Diet

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Originally published on mensphysique.com on Sunday, 09 December 2012. The original post was published with white text on white background, so the only way to read it on the site is to highlight the text. To make things easier for everyone, I have copied and pasted the article here for you to read.

http://www.rxmuscle.com/blogs/the-lab-supplement-school/7143-why-you-should-add-curcumin-to-your-diet.html
Curcumin diagram
Antioxidants have become a hot topic in combating disease in recent years, and the list of these substances has grown thanks to extensive research which has been conducted and disseminated to the public. A particularly powerful antioxidant is curcumin. Curcumin, an extract which is derived from turmeric, has been used in Asian curries for many centuries and has also been used for treatment of arthritis and other health conditions. Only recently has curcumin received attention from the United States regarding its remarkable benefits as a potent antioxidant.

Perhaps the most exciting potential benefit of curcumin is that it may help to prevent and treat cancer by inhibiting cancer cell growth and the growth of blood vessels which feed into tumors. There is some speculation that curcumin can prevent cancer cells from multiplying and is also capable of causing self-destruction of cancer cells. As if this wasn’t enough, there is a possibility that curcumin may prevent Alzheimer’s Disease by decreasing the accumulation of amyloid which characterizes this disease.

Here is a list of other benefits which curcumin confers:
· Accelerates wound healing
· Acts as a cleanser for the liver
· Regulates metabolism and assists in weight loss
· Reduces LDL cholesterol and raises HDL levels
· Decreases severity of inflammatory skin disorders such as psoriasis
· Acts as a natural painkiller

If these reasons are not enough to compel you to add curcumin supplementation into your meal plans, consider the fact that curcumin reduced the COX-2 enzyme in the body, thus decreasing the pain and swelling of arthritis. In fact, recent studies revealed that curcumin was even more effective than ibuprofen (Motrin, Advil) in its anti-inflammatory effects. One particular study in Italy which was conducted on 50 patients, all of whom had confirmed knee osteoarthritis, found a 58 percent decrease in reported overall pain and stiffness as well as an improvement in physical functioning among the curcumin group versus the control group.
Curcumin bottle
How To Take Curcumin
Some individuals may prefer to ingest curcumin in the form of straight turmeric powder which can be added to meals or tea. However, I prefer to take curcumin in capsule form. If you opt for the capsule version, look for formulations which contain piperine, or black pepper extract. Piperine augments the gastrointestinal absorption of curcumin. Recommended daily dosage is 400 to 600 milligrams per day. For acute flare-ups of arthritis or other musculoskeletal pain, you can double the dosage until the acute phase abates.

Supplements Women Need

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Originally published on RxGirl on Friday, 30 November 2012. The original post was published with white text on white background, so the only way to read it on the site is to highlight the text. To make things easier for everyone, I have copied and pasted the article here for you to read.

http://www.rxmuscle.com/rx-girl-articles/7082-supplements-women-need.html
Supps for women
The number of nutritional supplements which are available today can be pretty intimidating to those who are not familiar with the benefits which they confer on those who take them. If you also consider the performance supplements which are marketed to fitness-minded individuals, and which are marketed mostly to men, women are often left bewildered. Since it is my aim to address the issues of women in this article, I will not discuss general supplements such as multivitamins, CLA, fish oil, CoQ10 or the like. Rather, I will focus on supplements which have demonstrated efficacy in treating female-specific woes.

Biotin: This substance promotes growth of healthy hair and nails and is something I have taken daily for many years. Though I have horribly thin nails (and continue to suffer from them despite biotin), my hair has actually gotten considerably thicker in the past ten years, and I honestly believe that biotin has played a large role with respect to my hair health. Another great benefit of biotin is the demonstrated effect it has on regulation of blood glucose. I recommend taking the maximum dose possible, 5,000 micrograms per day.

Calcium: Calcium is a mineral which is a critical component of bone health. There are three mistakes I see people making when taking this supplement:
1. Taking it without Vitamin D or magnesium – Both Vitamin D and magnesium must be present in order for the body to be able to absorb calcium.
2. Taking it on an empty stomach – Calcium is best absorbed when taken with food.
3. Taking large doses at one time – The body is unable to absorb much more than 500 milligrams of calcium at one time. Since the general daily dose in women of childbearing age is 1,000 mg, supplementation should be broken up into 2 doses of 500 milligrams each per day.

DHEA: Dehydroepiandrosterone (DHEA) is a precursor hormone which is produced in the adrenal glands which is later converted to sex hormones such as estrogen and testosterone. Levels of DHEA fall with advancing age and can also decline as a result of exposure to stress. Signs of declining DHEA include stress, fatigue, memory loss, depression, dry skin, and decreased libido. Women are struggling with infertility may also find that DHEA will increase their fertility by promoting hormonal balance and ovulation. I generally feel that any woman over the age of 35 would benefit from supplementation with DHEA at 5 to 15 milligrams per day.

Folic Acid: Many women are aware that supplementation with folic acid decreases the risk of neural tube defects in a developing fetus, but not many know that folic acid has been proven to lower blood pressure in women and prevent development of hypertension. A daily dose of 800 micrograms is advised.
ALA: Alpha lipoic acid, or ALA for short, is effective in regulating blood glucose, optimizing carbohydrate consumption and reducing sugar cravings. Effective dose ranges are between 100 to 200 milligrams, taken two to three times daily.

Chromium Picolinate: Chromium picolinate can decrease sugar cravings and is effective at regulating blood glucose. A dose of 200 micrograms three times daily is optimal.

Vanadyl Sulfate: This is another supplement which can curb sugar cravings. Take 10 milligrams three times daily.

Phosphatidylserine Complex: This supplement supports the adrenal glands during stressful times. Those with poorly functioning adrenal glands should not take this supplement. A daily dose of 200 milligrams taken earlier in the day is recommended.

Melatonin: Melatonin is well known for its effectiveness in balancing out sleep patterns and treating insomnia. This is due to the fact that it reduces cortisol levels (cortisol is known as the stress hormone). Women who suffer from infertility should not take this as it can aggravate the condition. Start with 0.5 milligrams shortly before bedtime and slowly increase the dose by 0.5 mg increments ever few days until you get the desired effect. Do not take more than 5 mg in a dose. Some experts recommend that melatonin only be taken in the short term for isolated insomnia bouts.
Natural Woman
B-Complex – B-complex formulations consist of the following: B complex capsule contains the following vitamins: folic acid, thiamine (B1), riboflavin (B2), niacin (B3),panthothenic acid (B5), pyridoxine (B6), cyanocobalamin (B12) and biotin. This complex supports memory, improves mood, decreases anxiety and combats the effects of stress. It also boosts metabolism, thus increasing energy. I have encountered remarkable responses to B-complex in people who have suffered from depression and who did not respond to prescription antidepressants. I recommend 100 mg per day.

GLA: Gamma-linoleic acid can be very effective in treating the symptoms of PMS, such as menstrual cramps and breast tenderness, especially when taken in tandem with magnesium and vitamin B6. Take 500 to 1,000 milligrams per day.

Magnesium Glycinate: This is a highly bioavailable form of magnesium which helps not only with PMS but also with hot flashes which some menopausal women experience. Recommended dosage is 250 milligrams one to three times daily, and should be taken with food.

Vitamin B6: Vitamin B6 is effective in mellowing the symptoms of PMS, menopause, and morning sickness associated with early pregnancy. It is also effective for depression, acne, and bladder inflammation. Take between 50 to 600 milligrams per day in two to three divided doses.

Cranberry Extract: This is an excellent supplement for good urinary tract health, as it renders the inner bladder walls slippery so that bacteria are unable to adhere to them. Any women who have recurrent bladder infections should take this supplement at a daily dosage of 400 to 500 milligrams.

Diindolylmethane: This extract is found in cruceiferous vegetables such as broccoli and cauliflower and supports healthy estrogen metabolism by optimizing breakdown of excess estrogen. A great formula is DIM-Plus by Nature’s Way. Take two capsules per day.

Should You Block Cortisol Production?

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Originally published on mensphysique.com on Thursday, 01 November 2012

http://www.rxmuscle.com/blogs/the-lab-supplement-school/6894-should-you-block-cortisol-production.html
cortisol
Cortisol’s Functions

Cortisol has gotten a bad rap in recent years due to its nickname, the “stress hormone”. What occurs during times of excessive emotional stress? The adrenal glands respond by producing more cortisol in an effort to provide more energy and a higher pain threshold which is in keeping with the “fight-or-flight” response you may be familiar with. Normally, cortisol levels are at their highest in the morning then decrease progressively throughout the day, but if your body is placed under excessive stress, it may produce abnormally high levels of cortisol which disrupt this natural pattern. The resulting elevation in cortisol stimulates the metabolism of carbohydrates and fats and also triggers insulin release. These activities can result in an increased appetite and uncomfortable hunger pains. Blood glucose levels also rise as a result of excessive cortisol release, and if that glucose is not used for energy, it will be stored in the body’s fat reserves, particularly in the fat cells of the abdominal region.

An alarming consequence of excess cortisol release as a result of stress is the damage to the hippocampus and potential memory loss which can occur over time. Several studies have discovered that about one fourth of the hippocampus cells in the brain are lost as we age. Since the hippocampus is responsible for giving feedback to the cerebral cortex in order to prevent production of excess cortisol, such feedback is impaired and could lead to memory loss over time.

However, while it is true that cortisol is responsible for responding to stressful situations, it is also essential for a number of important functions in the body, including regulation of blood pressure, glucose metabolism, immune system support, memory support and regulation of blood sugar. Keeping cortisol release at a balanced and normal range is the key to optimizing its beneficial effects.

Catabolism, Anabolism and Cortisol

Cortisol is a potent catabolic agent and has been shown to cause significant loss of muscle mass in sedentary individuals. When cortisol is released into the bloodstream, it binds to receptors on muscle cells and activates the ATP-dependent ubiquitin/proteasome pathway which causes the body to literally consume its own muscle tissue. It’s a disturbing thought, but the upside is that weight training is effective in counteracting some of cortisol’s direct catabolic actions. The strange paradox is that training both reduces cortisol’s direct catabolic effects and increases the body’s secretion of the substance. Cortisol also slows the body’s anabolic drive by inhibiting the release of testosterone, human growth hormone and insulinlike growth factor 1. Thankfully, weight training once again blocks this anti-anabolic action to some extent, but this block only occurs in the trained muscles.

Another bizarre paradox with cortisol is found with protein absorption. Eating any meal will trigger cortisol release, but proteins are the most potent cortisol releasers. Cortisol release can be blocked by administering alpha-1-blockers before a protein meal, but this will also adversely affect protein absorption. What this boils down to is that cortisol must be released in order to properly assimilate proteins. Keep in mind that protein-induced cortisol release is very brief, while cortisol released as a result of stress persists for a much longer period of time.

Controlling Cortisol Release

A certain level of cortisol secretion is normal. However, if you are interested in controlling excessive cortisol release, you may want to consider taking certain supplements. The most prudent manner in which to do this is to get a blood test beforehand which will determine whether you actually have abnormally high cortisol levels.

GlutamineComplex300L-glutamine: Athletes who supplement with L-glutamine are well aware of its mass building and reparative effects, but L-glutamine also halts cravings for simple carbohydrates, thus aiding in stabilizing blood sugar in individuals who have high cortisol levels.

Theanine: Theanine is naturally found in green tea and has been studied for its calming effects on the nervous system. It works by triggering dopamine and gamma aminobutyric acid (GABA) release, which serve to protect the hippocampus.

L-lysine and L-arginine: Combination oral supplementation of these two amino acids have been proven to reduce anxiety and restore cortisol to basal levels.

B-Complex Vitamins: All of the B vitamins work synergistically in adrenal hormone production, especially vitamin B-6, pantothenic acid and niacin. Not only do they support adrenal hormone production, they also protect against the effects of excess cortisol.

Vitamin C: When the body is placed under stress, free radicals are produced which cause the body to use up vitamin C as a protective mechanism for cells. Since we are unable to produce our own vitamin C, it must be ingested regularly. In fact, vitamin C intake should be increased during stressful times.

Zinc: Stress-related cortisol surges will often trigger sugar cravings which, when indulged, may result in a zinc deficiency due the fact that sugar binds with zinc and is excreted. However, individuals who supplement with zinc and refrain from sugar indulgences benefit from a protective effect which zinc confers. One study in particular, “Zinc Acutely and Temporarily Inhibits Adrenal Cortisol Secretion in Humans” by J. Brandao-Neto et al in the January 1990 issue of the journal “Biological Trace Element Research”, administered zinc to some subjects and placebo to the control group. The group which was given zinc supplementation showed an acute drop in cortisol levels compared with the control group.

Magnesium: Studies by Dr. Hans Selye revealed that when the human body shifts from an acute “fight or flight” reaction to a chronic stress response, the high levels of cortisol and norepinephrine result in magnesium depletion. When the body is deficient in magnesium, one becomes predisposed to panic attacks which lead to more stress and more depletion. Studies have also shown that 80 percent of the American population is deficient in magnesium. By supplementing with magnesium, one can boost serotonin production and provide protection against the harmful effects of excess cortisol.

ZMA: ZMA, which stands for Zinc monomethionine aspartate and Magnesium Aspartate, is a popular sports supplement which is comprised of zinc, magnesium and vitamin B6. The proportion of ingredients usually seen is 20-30 mg zinc, 400-500 mg magnesium and 10 mg of vitamin B6. This supplement meets the body’s magnesium requirement, and the zinc and vitamin B6 allegedly increase strength levels.

Pregnenalone: Pregnenalone is a precursor to progesterone and DHEA. Since progesterone has a protective effect against the effects of estrogen and cortisol, and since DHEA causes cortisol levels to fall, pregnenalone can be an effective supplement in controlling cortisol excess.

Phosphatidylserine: This phospholipid is an essential building block for cells which is extremely effective in reducing cortisol levels in response to physical stress. Phosphatidylserine can also have a positive effect on one’s mood.

Bodyfuse D-MassTestosterone Boosters: These substances can moderate the release of cortisol in response to exercise.

Growth hormone boosters: These substances also control exercise-induced cortisol release while leaving basal cortisol release unaffected.

Carbohydrate drinks: When a workout is lengthy, blood glucose levels fall, resulting in hypoglycemia which triggers the release of cortisol. Consuming a carbohydrate beverage can prevent this drop in blood glucose while also maintaining insulin at a high level.

To Suppress, Or Not To Suppress…Cortisol, that is:

Many of you are aware that cortisol can simultaneously cause degradation of protein and impair protein synthesis. However, there is a danger in taking supplements to inhibit cortisol release if your basal cortisol levels are already low. When basal cortisol levels are below normal, metabolism is disrupted, blood sugar drops and glycogen stores are diminished. Low cortisol levels also cause blood pressure to plummet along with a decrease in cardiac output. Diminished cortisol also causes hyperactivity in the melanocytes which produce skin pigment, precipitating dark discoloration.

If that isn’t enough, low cortisol results in impaired immune response, weakness and dehydration. When infection, excessive sweating or surgical trauma occur in such an environment, an adrenal crisis can occur. If such a crisis is pronounced, a whole host of symptoms can manifest, a number of which are life threatening. The most severe of these symptoms are loss of consciousness, low blood pressure, seizures, shock and coma.

As stated before, it is a good idea to check your cortisol levels before taking any type of supplement which is designed to control cortisol release.